Preliminary Study of Hydrodynamics in Fetal Mice Using <sup>17</sup>O-MRI [Presidential Award Proceedings]

17O-MRI is expected to have clinical applications owing its high biocompatibility and ability directly track water movement. Fetuses grow with an active exchange of the mother ; therefore, understanding dynamics mother-fetus amniotic fluid cycle important. However, movement cannot be measured using echocardiography, Gd contrast-enhanced MRI contraindicated in pregnant women. In this study, 17O-labeled saline was administered measure fetal mice. The results were compared signal changes induced by administration. Dynamic scans mice successfully obtained. images showed that differed from those obtained contrast agent. future, efforts will made improve temporal spatial resolution as well investigate possibility detecting correlations between signals observed various tissues.